American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast
Got Guts: Embracing our heterogeneity

Got Guts: Embracing our heterogeneity

July 20, 2022

In a rapidly evolving era of single cell technologies, the authors of "Stiffness is associated with hepatic stellate cell heterogeneity during liver fibrosis" explain the mechanism of an amplification loop during liver fibrosis. By deciphering how stiffness macro and microscopic heterogeneity promote differential gene expression in hepatic stellate cell sub-populations, the authors find a novel stiffness-promoted molecule involved in liver fibrosis progression. Get to know authors Dr. Enis Kostallari and Dr. Vijay Shah of the Mayo Clinic as they discuss their recently published manuscript and what life is like as a researcher with Editor-in-Chief Professor Mark Frey. 

 

https://journals.physiology.org/journal/ajpgi 

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Got Guts: HOPX+ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia

Got Guts: HOPX+ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia

June 24, 2022

Get to know senior author Dr. Liara M. Gonzalez of North Carolina State University as she discusses the recently published paper entitled "HOPX+ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia" with EIC Prof. Mark Frey.  This paper supports that rISCs are resistant to ischemic injury and likely an important source of cellular renewal following near-complete epithelial loss. Furthermore, the authors have evidence that HOPX controls ISC activity state and may be a critical signaling pathway during ISC-mediated repair. Finally, they use multiple novel methods to evaluate ISCs in a translationally relevant large animal model of severe intestinal injury and provide evidence for the potential role of rISCs as therapeutic targets. 

Amy Stieler Stewart, Cecilia Renee Schaaf, Jennifer A. Luff, John M. Freund, Thomas C. Becker, Sara R. Tufts, James B. Robertson, and Liara M. Gonzalez

https://doi.org/10.1152/ajpgi.00165.2021

Got Guts: A new approach to treat gastrointestinal motility disorders

Got Guts: A new approach to treat gastrointestinal motility disorders

May 13, 2022

Looking for a new pharmacological approach to treat gastrointestinal motility disorders?

In this podcast authors Dr. Daniel Poole and Dr. Simona Carbone of Monash University discuss their recent paper, where they investigated the therapeutic potential of a positive allosteric modulator to enhance endogenous delta-opioid receptor signaling in the gut. Take a listen today! 

Jesse J. DiCello, Simona E. Carbone, Ayame Saito, Vi Pham, Agata Szymaszkiewicz, Arisbel B. Gondin, Sadia Alvi, Kiliana Marique, Priyank Shenoy, Nicholas A. Veldhuis, Jakub Fichna, Meritxell Canals, Arthur Christopoulos, Celine Valant, and Daniel P. Poole 

https://doi.org/10.1152/ajpgi.00297.2021

Unraveling the mysteries of stem cells in inflammatory bowel disease

Unraveling the mysteries of stem cells in inflammatory bowel disease

April 28, 2022

Three investigators at Children's Hospital Los Angeles, Nandini Girish, Dr. Cambrian Liu, and Dr. Brent Polk, talk about their recent work to visualize the fates and functions of epithelial stem cells in models of inflammatory bowel disease with Editor-in-Chief Professor Mark Frey. The investigators discuss their diverse backgrounds, reveal how they started the work, and begin a spirited debate on the relative values of minivans and dogs and cats.

Check out the manuscript associated with this podcast here:

https://doi.org/10.1152/ajpgi.00248.2020

Got Guts: Behind the science with an Organoid Diva

Got Guts: Behind the science with an Organoid Diva

April 15, 2022

Many times we read a manuscript but don’t really get to know the amazing author behind the great science.  Behind those black typewritten letters that spell a scientists name lies a person that is usually creative, intelligent, quirky, and fun.  This is certainly the case with the author of “Use of human tissue stem cell-derived organoid cultures to model enterohepatic circulation”, Dr. Sarah Blutt.  Please listen in as we learn a little bit about one of the fields Organoid Divas and what makes her tick as we discuss organoids as a biological toll booth and other topics.

Check out the manuscript associated with this podcast here: https://doi.org/10.1152/ajpgi.00177.2021 

Got Guts: What’s Cooking at EB 2022

Got Guts: What’s Cooking at EB 2022

March 28, 2022

Welcome to AJP- Gastrointestinal Liver’s Physiology’s Podcast series, Got Guts? Our first episode is a  joint effort with Dr. Pradeep Dudeja, Chair of the GI and Liver Section and Dr. Karen Edelblum, Chair of GI and Liver Program Committee with host Editor-In-Chief, Professor Mark Frey. In this podcast we will be talking about all things Experimental Biology 2022. For more information on Experimental Biology 2022 please go to www.experimentalbiology.org . To learn more about the journal and section please go to www.physiology.org. If you are interested in submitting a manuscript and have questions, please email Jami Jones at jjones@physiology.org 

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