American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

”Got Guts” the Micro Version with Steven Hutchens and Somshuvra Mukhopadhyay

In this podcast  Steven Hutchens and Dr. Somshuvra Mukhopadhyay of the University of Texas at Austin discuss the recently published research titled "Hepatic and intestinal manganese excretion are both required to regulate brain manganese during elevated manganese exposure." 

 

NEW & NOTEWORTHY This article shows that, in contrast with expectations from prior studies and physiological conditions, excretion of manganese by the intestines and liver is equally important in controlling brain manganese during human-relevant manganese exposure. The results provide foundational insights about the interorgan mechanisms that control brain manganese homeostasis at the organism level and have important implications for the development of therapeutics to treat manganese-induced neurological disease.

 

Article Citation: 

Hepatic and intestinal manganese excretion are both required to regulate brain manganese during elevated manganese exposure

Steven Hutchens, Thomas P. Jursa, Ashvini Melkote, Stephanie M. Grant, Donald R. Smith, and Somshuvra Mukhopadhyay

American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 325:3, G251-G264

”Got Guts” the Micro Version with Jihane N. Benhammou

In this episode, Dr. Jihane N. Benhammou of UCLA discusses the recently published article titled "Lipophilic statins inhibit YAP coactivator transcriptional activity in HCC cells through Rho-mediated modulation of actin cytoskeleton."

 

NEW & NOTEWORTHY Statins are widely used for the treatment of cardiovascular diseases. Recently, their use has been associated with a decrease in the incidence of hepatocellular carcinoma (HCC); however, their mechanism(s) has remained elusive. In this study, we delineate the mechanism by which statins affect the Yes-associated protein (YAP), which has emerged as a key oncogenic pathway in HCC. We investigate each step of the mevalonate pathway and demonstrate that statins regulate YAP via Rho GTPases.

 

Article Citation:

Lipophilic statins inhibit YAP coactivator transcriptional activity in HCC cells through Rho-mediated modulation of actin cytoskeleton

Jihane N. Benhammou, Bo Qiao, Arthur Ko, James Sinnett-Smith, Joseph R. Pisegna, and Enrique Rozengurt

American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 325:3, G239-G250

”Got Guts” the Micro Version with Francisco Pascual and Samuel Camilli

In this podcast coauthors Francisco Pascual, and Samuel Camilli of Morsani College of Medicine, University of South Florida discuss the recently published Perspectives titled "Mind-body connection: metabolite 4-ethylphenyl linked to anxiety behavior and oligodendrocyte modification in autism spectrum disorder."

 

Article Citation:

Mind-body connection: metabolite 4-ethylphenyl linked to anxiety behavior and oligodendrocyte modification in autism spectrum disorder

Francisco Pascual, Samuel Camilli, Richard F. Lockey, and Narasaiah Kolliputi

American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 324:6, G422-G425

 

”Got Guts” the Micro Version with Theo A.T.G. van Kempen and Gavin M. Boerboom

In this podcast Prof. Theo A.T.G. van Kempen of North Carolina State University and Dr. Gavin M. Boerboom of Trouw Nutrition discuss their recently published perspectives paper titled "Is the intestinal mucous layer a natural deep eutectic solvent-based digestion matrix?"

 

Article Citation:

Is the intestinal mucous layer a natural deep eutectic solvent-based digestion matrix?

Theo A.T.G. van Kempen and Gavin M. Boerboom

American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 324:6, G438-G441

”Got Guts” the Micro Version with Jessica A. Breznik

In this podcast first author Dr. Jessica A. Breznik of McMaster University, discusses the recently published manuscript titled "Diet-induced obesity alters intestinal monocyte-derived and tissue-resident macrophages and increases intestinal permeability in female mice independent of tumor necrosis factor." 

 

NEW & NOTEWORTHY We found that diet-induced obesity in female mice has tissue- and time-dependent effects on intestinal paracellular permeability as well as monocyte-derived and tissue-resident macrophage numbers, surface marker phenotype, and intracellular production of the cytokines IL-10 and TNF. These changes were not mediated by TNF.

 

Article Citation: 

Diet-induced obesity alters intestinal monocyte-derived and tissue-resident macrophages and increases intestinal permeability in female mice independent of tumor necrosis factor

Jessica A. Breznik, Jennifer Jury, Elena F. Verdú, Deborah M. Sloboda, and Dawn M. E. Bowdish

American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 324:4, G305-G321

”Got Guts” the Micro Version with Gene Lamanilao

In this micro podcast Dr. Gene G. Lamanilao The University of Tennessee Health Science Center, College of Medicine gives the listeners an overview the recently published manuscript titled "Key hepatoprotective roles of mitochondria in liver regeneration." 

 

Treatment of advanced liver disease using surgical modalities is possible due to the liver’s innate ability to regenerate following resection. Several key cellular events in the regenerative process converge at the mitochondria, implicating their crucial roles in liver regeneration. Mitochondria enable the regenerating liver to meet massive metabolic demands by coordinating energy production to drive cellular proliferative processes and vital homeostatic functions. Mitochondria are also involved in terminating the regenerative process by mediating apoptosis. Studies have shown that attenuation of mitochondrial activity results in delayed liver regeneration, and liver failure following resection is associated with mitochondrial dysfunction. Emerging mitochondria therapy (i.e., mitotherapy) strategies involve isolating healthy donor mitochondria for transplantation into diseased organs to promote regeneration. This review highlights mitochondria’s inherent role in liver regeneration.

 

Article Citation: 

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Key hepatoprotective roles of mitochondria in liver regeneration

Gene G. Lamanilao, Murat Dogan, Prisha S. Patel, Shafquat Azim, Disha S. Patel, Syamal K. Bhattacharya, James D. Eason, Canan Kuscu, Cem Kuscu, and Amandeep Bajwa

American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 324:3, G207-G218

Got Guts: Small Intestine Neuroendocrine Tumor: Its cell-of-origin has a curious fate of tumorigenesis

Take a listen to our latest podcast with coauthor Dr. Yoshi Sei as he discusses the recently published manuscript "Tissue- and cell-specific properties of enterochromaffin cells affect the fate of tumorigenesis toward nonendocrine adenocarcinoma of the small intestine" with Editor in Chief Professor Mark Frey. Small intestinal neuroendocrine tumors are of putative enterochromaffin (EC) cell origin and are the most common malignancy in the small intestine, followed by adenocarcinoma. Dr Sei, explains how tissue- and cell-specific properties of EC cells such as cell turnover, migration, and dedifferentiation, affect their fate of tumorigenesis.

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Got Guts: The 411 of GI and Liver Section at American Physiology Summit 2023

Take a listen to our latest podcast where the magnificent Dr. Karen Edelblum, chair of the GI and Liver Section discusses what's happening at our first ever American Physiology Summit, April 20-23rd in Long Beach California.

Registration Deadline for American Physiology Summit is March 31, 2023

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Got Guts: Initiation and severity of experimental pancreatitis are modified by phosphate

Get to know author Dr. Rodger Liddle (Duke University) in this latest podcast as he goes over his recently published manuscript "Initiation and severity of experimental pancreatitis are modified by phosphate" with Editor in Chief Professor Mark Frey. 

 

New and Noteworthy-Impaired ATP synthesis disrupts acinar cell homeostasis and is an early step in pancreatitis. We report that reduced phosphate availability impairs mitochondrial function and worsens pancreatic injury. Phosphate supplementation improves mitochondrial function and protects against experimental pancreatitis, raising the possibility that phosphate supplementation may be useful in treating pancreatitis.

 

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Got Guts: Unravelling the NF-kappa B enigma in the gut

In this podcast authors Prof D. Mark Pritchard and Dr. Carrie Duckworth of the University of Liverpool, discuss their recently published manuscript “Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa” with Editor-in-Chief Prof. Mark Frey. Novel transcriptomic analysis of murine proximal intestinal mucosa revealed an unexpected B cell signature in Nfkb2-/- mice. In depth analysis revealed a defect in the CD38+ B cell population and a gut-specific dysregulation of immunoglobulin levels. Take a listen to this latest podcast today!

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