"Got Guts" The Micro Version: Effects of L. Casei-Fermented Milk on Mice with DSS Colitis

Coauthors Mélanie G. Gareau and Maria L. Marco delve into the findings of their latest research titled "Milk and Lacticaseibacillus paracasei BL23 effects on intestinal responses in a murine model of colitis." This study marked the first exploration into sex-dependent responses to probiotic Lacticaseibacillus paracasei and milk, as well as the potential of the dairy matrix to enhance probiotic protection against colitis. Surprisingly, female mice exhibited greater sensitivity to colonic injury compared to their male counterparts, and neither treatment effectively mitigated inflammation in both sexes. These sex-specific reactions may be attributed to variances in the baseline proportions of Akkermansia in the gut microbiome of female mice, shedding light on the intricate interplay between sex, diet, probiotics, and colitis outcomes.

 

Article Citation: 

Milk and Lacticaseibacillus paracasei BL23 effects on intestinal responses in a murine model of colitis

Glory Bui, Cristina Torres-Fuentes, Matteo M. Pusceddu, Mélanie G. Gareau, and Maria L. Marco

American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 326:6, G659-G675