Uncovering the Gut-Adipose-Liver Axis: Microbiota Encroachment and Metabolic Dysfunction in MASLD

In this episode, coauthors Daria Igudesman and Karen D. Corbin discuss their team’s recently published study, "Microbiota encroachment and a gut-adipose-liver axis in metabolic dysfunction-associated steatotic liver disease." This first-in-human study explores how changes in the gut microbiota may contribute to metabolic dysfunction through a gut-adipose-liver axis. The researchers found that colonic expression of insulin and lipid-related genes may link microbial encroachment in the colon with adipose tissue insulin resistance and the development of metabolic dysfunction-associated steatotic liver disease (MASLD). Tune in to learn how these findings offer new insights into the complex interplay between the gut microbiome and metabolic health.

 

Microbiota encroachment and a gut-adipose-liver axis in metabolic dysfunction-associated steatotic liver disease

Daria Igudesman, GongXin Yu, Charlene Dauriat, Torfay Roman, Maryam R. Kashi, Elizabeth Blakley, Benoit Chassaing, and Karen D. Corbin

American Journal of Physiology-Gastrointestinal and Liver Physiology 2025 329:1, G201-G214