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Podcasts of the American Journal of Physiology-Gastrointestinal and Liver Physiology
Episodes
Friday Dec 01, 2023
Friday Dec 01, 2023
In this episode authors Katherine L. Prowse,, and Elyanne M. Ratcliffe of McMaster University, discuss their recently published article titled “Effects of in utero exposure to fluoxetine on the gastrointestinal tract of rat offspring.”
NEW & NOTEWORTHY There is increasing recognition of the relevance of in utero and early postnatal exposures in the developmental programming of the gastrointestinal tract. Perinatal exposure to selective serotonin reuptake inhibitors and antidepressant medications is of particular relevance as they are commonly prescribed during pregnancy, and serotonergic pathways play key roles during gastrointestinal development and in postnatal homeostasis. Here, we provide a comprehensive evaluation of clinically relevant outcomes of gastrointestinal motility and susceptibility to colitis in fluoxetine-exposed offspring and highlight changes in colonic serotonergic neurons at the peak of perinatal fluoxetine exposure with sex-dependent changes in serotonin signaling and colonic motility in adulthood.
Article Citation:
Effects of in utero exposure to fluoxetine on the gastrointestinal tract of rat offspring
Katherine L. Prowse, Harriet Law, Sergio Raez-Villanueva, Filip Markovic, Megan Wang, Rajka Borojevic, Sean P. Parsons, Alexander D. Vincent, Alison C. Holloway, and Elyanne M. Ratcliffe
American Journal of Physiology-Gastrointestinal and Liver Physiology
2023 325:6, G528-G538
Friday Nov 17, 2023
Friday Nov 17, 2023
Diego Alvarez de la Rosa of the University of La Laguna discusses the recently published manuscript titled “Decaying kidney function during cirrhosis correlates with remodeling of distal colon aldosterone target gene expression.”
NEW & NOTEWORTHY Liver cirrhosis progression significantly alters ion transporter subunit expression in the rat distal colon, a change that correlated well with declining kidney function and the severity of the disease. Natalia Serrano-Morillas et al. data suggests that the steroid hormone aldosterone participates in this homeostatic response to maintain electrolyte balance.
Article Citation:
Natalia Serrano-Morillas, Carlos González-Alayón, Arianna Vastola-Mascolo, Ana E. Rodríguez-Rodríguez, Guadalberto Hernández, Esteban Porrini, Manuel Hernández-Guerra, and Diego Alvarez de la Rosa
American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 325:4, G306-G317
Tuesday Oct 17, 2023
Tuesday Oct 17, 2023
In this podcast lead author Dr. Stella Liong of RMIT University, discusses the recently published manuscript titled “Influenza A virus infection during pregnancy causes immunological changes in gut-associated lymphoid tissues of offspring mice.”
NEW & NOTEWORTHY Influenza A virus (IAV) infection during pregnancy is associated with changes in gut-associated lymphoid tissue (GALT) in the offspring in a region-dependent manner. Neutrophils and monocytes/macrophages were elevated in the cecal patch of offspring from infected dams. This increase in innate immune cell infiltration was not observed in the Peyer’s patches. T cells were also elevated in the cecal patch but not in the Peyer’s patches.
Article Citation:
Stella Liong, Mark A. Miles, Mitra Mohsenipour, Felicia Liong, Elisa L. Hill-Yardin, and Stavros Selemidis
American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 325:3, G230-G238
Monday Oct 09, 2023
Monday Oct 09, 2023
First author, Dr. Kalidas Ramamoorthy of the University of California, Irvine discusses the recently published paper titled “miR-122-5p is involved in posttranscriptional regulation of the mitochondrial thiamin pyrophosphate transporter (SLC25A19) in pancreatic acinar cells.”
NEW & NOTEWORTHY This study shows that the expression and function of mitochondrial TPP transporter (MTPPT) are subject to posttranscriptional regulation by miRNA-122-5p in pancreatic acinar cells.
Article Citation:
Kalidas Ramamoorthy, Subrata Sabui, Kameron I. Manzon, Appakalai N. Balamurugan, and Hamid M. Said
American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 325:4, G347-G355
Wednesday Sep 27, 2023
Wednesday Sep 27, 2023
In this podcast Steven Hutchens and Dr. Somshuvra Mukhopadhyay of the University of Texas at Austin discuss the recently published research titled "Hepatic and intestinal manganese excretion are both required to regulate brain manganese during elevated manganese exposure."
NEW & NOTEWORTHY This article shows that, in contrast with expectations from prior studies and physiological conditions, excretion of manganese by the intestines and liver is equally important in controlling brain manganese during human-relevant manganese exposure. The results provide foundational insights about the interorgan mechanisms that control brain manganese homeostasis at the organism level and have important implications for the development of therapeutics to treat manganese-induced neurological disease.
Article Citation:
American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 325:3, G251-G264
Friday Sep 22, 2023
Friday Sep 22, 2023
In this episode, Dr. Jihane N. Benhammou of UCLA discusses the recently published article titled "Lipophilic statins inhibit YAP coactivator transcriptional activity in HCC cells through Rho-mediated modulation of actin cytoskeleton."
NEW & NOTEWORTHY Statins are widely used for the treatment of cardiovascular diseases. Recently, their use has been associated with a decrease in the incidence of hepatocellular carcinoma (HCC); however, their mechanism(s) has remained elusive. In this study, we delineate the mechanism by which statins affect the Yes-associated protein (YAP), which has emerged as a key oncogenic pathway in HCC. We investigate each step of the mevalonate pathway and demonstrate that statins regulate YAP via Rho GTPases.
Article Citation:
American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 325:3, G239-G250
Tuesday Sep 05, 2023
Tuesday Sep 05, 2023
In this podcast coauthors Francisco Pascual, and Samuel Camilli of Morsani College of Medicine, University of South Florida discuss the recently published Perspectives titled "Mind-body connection: metabolite 4-ethylphenyl linked to anxiety behavior and oligodendrocyte modification in autism spectrum disorder."
Article Citation:
American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 324:6, G422-G425
Tuesday Aug 29, 2023
Tuesday Aug 29, 2023
In this podcast Prof. Theo A.T.G. van Kempen of North Carolina State University and Dr. Gavin M. Boerboom of Trouw Nutrition discuss their recently published perspectives paper titled "Is the intestinal mucous layer a natural deep eutectic solvent-based digestion matrix?"
Article Citation:
American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 324:6, G438-G441
Monday Aug 21, 2023
Monday Aug 21, 2023
In this podcast first author Dr. Jessica A. Breznik of McMaster University, discusses the recently published manuscript titled "Diet-induced obesity alters intestinal monocyte-derived and tissue-resident macrophages and increases intestinal permeability in female mice independent of tumor necrosis factor."
NEW & NOTEWORTHY We found that diet-induced obesity in female mice has tissue- and time-dependent effects on intestinal paracellular permeability as well as monocyte-derived and tissue-resident macrophage numbers, surface marker phenotype, and intracellular production of the cytokines IL-10 and TNF. These changes were not mediated by TNF.
Article Citation:
American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 324:4, G305-G321
Monday Aug 14, 2023
Monday Aug 14, 2023
In this micro podcast Dr. Gene G. Lamanilao The University of Tennessee Health Science Center, College of Medicine gives the listeners an overview the recently published manuscript titled "Key hepatoprotective roles of mitochondria in liver regeneration."
Treatment of advanced liver disease using surgical modalities is possible due to the liver’s innate ability to regenerate following resection. Several key cellular events in the regenerative process converge at the mitochondria, implicating their crucial roles in liver regeneration. Mitochondria enable the regenerating liver to meet massive metabolic demands by coordinating energy production to drive cellular proliferative processes and vital homeostatic functions. Mitochondria are also involved in terminating the regenerative process by mediating apoptosis. Studies have shown that attenuation of mitochondrial activity results in delayed liver regeneration, and liver failure following resection is associated with mitochondrial dysfunction. Emerging mitochondria therapy (i.e., mitotherapy) strategies involve isolating healthy donor mitochondria for transplantation into diseased organs to promote regeneration. This review highlights mitochondria’s inherent role in liver regeneration.
Article Citation:
American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 324:3, G207-G218