American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

Got Guts: Embracing our heterogeneity

July 20, 2022

In a rapidly evolving era of single cell technologies, the authors of "Stiffness is associated with hepatic stellate cell heterogeneity during liver fibrosis" explain the mechanism of an amplification loop during liver fibrosis. By deciphering how stiffness macro and microscopic heterogeneity promote differential gene expression in hepatic stellate cell sub-populations, the authors find a novel stiffness-promoted molecule involved in liver fibrosis progression. Get to know authors Dr. Enis Kostallari and Dr. Vijay Shah of the Mayo Clinic as they discuss their recently published manuscript and what life is like as a researcher with Editor-in-Chief Professor Mark Frey. 

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